Paeoniflorin

Paeoniflorin

Product Name: Paeoniflorin
Appearance: Brownish Yellow fine powder
CAS NO: 23180-57-6
MF: C23H28O11

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Product details

Product Name: Paeoniflorin

Other Name: None

Appearance: Brownish Yellow fine powder

CAS NO: 23180-57-6

MF: C23H28O11

MW: 480

Test Method: HPLC

Physical Property: Mp 196 °C, soluble in water, methanol and ethanol

Function: 

1). To clear heat and cool blood;

2). To remove stagnant blood and reduce swelling

3). Febrile diseases in which exogenous pathogenic heat enters into the nutritive and blood levels manifested asmaculopapule, vomiting with blood, epistaxis, and deep red tongue proper. Red peony (Chishao) is used with Freshrehmannia root (Shengdihuang) and Moutan bark (Mudanpi).

4). Blood stagnation manifested as dysmenorrhea, amenorrhea, acute inflammation with red swelling and pain from

external injury. Red peony (Chishao) is used with Chuanxiong rhizome (Chuanxiong), Chinese angelica root (Danggui),

Peach seed (Taoren) and Safflower (Honghua).

5). Boils, carbuncles and furuncles. Red peony (Chishao) is used with Honeysuckle flower (Jinyinhua) and Forsythia fruit (Lianqiao)

Packing:

1.20mg/vial,1g/vial,5g/vial,10g/vial.       

2.aluminum foil bag.

3.25kg paper drum with double plastic food grade bags inside.

4. pharmaceutical aluminum tin.

5. according to customer request.

Description:

Paeonia lactiflora (Chinese peony or common garden peony) is a species of herbaceous perennial flowering plant in the family

Paeoniaceae, native to central and eastern Asia from eastern Tibet across northern China to eastern Siberia.

Paeonia lactiflora was known as the white peony (P. albiflora) when first introduced into Europe. It was brought to England in the mid-18th century, and is the parent of most modern varieties. There are several hundred selected cultivars in a range of colours, sizes and forms; many have double flowers, with the stamens modified into additional petals.There are many colors now available, from pure milk white, to pink, rose, and near red, along with single to fully double forms. They are prolific bloomers, and have become the main source of peonies for the cut flower business.

Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. This compound reverses guanethidine-induced hypotension by activating Adenosine A1 R (the central Adenosine A1-Rs) in the brain.

Quantification of paeoniflorin, the principal bioactive component of Paeoniae radix, in mice plasma following oral administration of Paeoniae radix extract was achieved by using a simple and rapid high-performance liquid chromatographic method. The calibration curve for paeoniflorin was linear (r2 = 0.998) over the concentration range 10-200 ng/ml. The coefficients of variation of intra- and inter-day assays were 15.04, 7.31, 6.14, 6.55, 6.63% and 12.71, 6.07, 3.61, 5.51, 4.52% at concentrations of 10, 60, 100, 160, 200 ng/ml, respectively. The recoveries of paeoniflorin from mice plasma were found to be 74.49, 76.83, 80.38 and 80.56% for concentrations of 30, 80, 120 and 160 ng/ml, respectively. The plasma concentration-time curves were fitted with mean terminal half-lives (t(1/2)) of 94.16 min.

Paeoniflorin (PF) is the chief active component of paeonia, with diverse pharmacological actions and wide application. Recently, the effect of PF on nervous system has attracted increasingly more attention. According to current study findings, PF can ameliorate the decline of memory and learning capacities in many dementia model animals, and have effect in protecting the cerebral ischemia injury, treating Parkinson's disease, reliving pain and improving neural synapse plasticity. Thought its mechanism has not been clarified, current findings show that adenosine A1 receptor plays an important role, while M cholinergic receptor, opiate receptor, calcium ion channel and NF-KB may also play a part in paeoniflorin's effect on nervous system.

 

 


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