Silymarin

Silymarin

Product Name: Silymarin
Other Name: Milk Thistle Extract
Appearance: Yellow powder
CAS NO: 65666-07-1

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Product details

Product Name: Silymarin

Other Name: Milk Thistle Extract

Appearance: Yellow powder

CAS NO: 65666-07-1

MF: C25H22O10

MW: 482.44

Test Method: UV

Physical Property: Tasteless, odourless, soluble in acetone, ethyl acetate, ethanol and methanol, hardly soluble in chloroform, insoluble in water.

Function: 

1.Protecting liver.

2.Preventing liver disease

3.Increasing function of liver

4.Regenerating liver cell

5.Anti-atherosclerotic 

Packing:

1.20mg/vial,1g/vial,5g/vial,10g/vial.       

2.aluminum foil bag.

3.25kg paper drum with double plastic food grade bags inside.

4. pharmaceutical aluminum tin.

5. according to customer request.

Description:

Silybum marianum has other common names include cardus marianus, milk thistle,[1] blessed milk thistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle. This species is an annual or biennial plant of the Asteraceae family. This fairly typical thistle has red to purple flowers and shiny pale green leaves with white veins. Originally a native of Southern Europe through to Asia, it is now found throughout the world.

The flavonoid silymarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties. Their mechanisms of action are still poorly understood. However, the data in the literature indicate that silymarin and silibinin act in four different ways:as antioxidants, scavengers and regulators of the intracellular content of glutathione; as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; as promoters of ribosomal RNAsynthesis, stimulating liver regeneration; and as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures hepatoprotection appears to be free radical scavenging. Anti-inflammatory and anticarcinogenic properties have also been documented.

Silymarin is able to neutralise the hepatotoxicity of several agents, including Amanita phalloides, ethanol, paracetamol (acetaminophen) and carbon tetrachloride in animal models. The protection against A phalloides is inversely proportional to the time that has elapsed since administration of the toxin. Silymarin protects against its toxic principle?

amanitin by preventing its uptake through hepatocyte membranes and inhibiting the effects of tumour necrosis factor- , which exacerbates lipid peroxidation. 

Clinical trials have shown that silymarin exerts hepatoprotective effects in acute viral hepatitis, poisoning by A phalloides, toxic hepatitis produced by psychotropic agents and alcohol-related liver disease, including cirrhosis, at daily doses ranging from 280 to 800mg, equivalent to 400 to 1140mg of standardised extract. Hepatoprotection has been documented by improvement in liver function tests; moreover, treatment with silymarin was associated with an increase in survival in a placebo-controlled clinical trial in alcoholic liver disease.

Pharmacokinetic studies have shown that silymarin is absorbed by the oral route and that it distributes into the alimentary tract (liver, stomach, intestine, pancreas). It is mainly excreted as metabolites in the bile, and is subject to enterohepatic circulation. Toxicity is very low, the oral 50% lethal dose being 10 000 mg/kg in rats and the maximum tolerated dose being 300 mg/kg in dogs. Moreover, silymarin is devoid of embryotoxic potential.

In conclusion, silymarin is a well tolerated and effective antidote for use in hepatotoxicity produced by a number of toxins, including A phalloides, ethanol and psychotropic drugs. Numerous experimental studies suggest that it acts as a free radical scavenger, with other liver-specific properties that make it a unique hepatoprotective agent.


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