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Xi'an Hao-Xuan Bio-Tech Co.,Ltd | Updated: May 16, 2016

Tetrandrine is an alkaloid that was isolated from the root of the Asian herb Stephania tetrandra,belongs bisbenzylisoquinoline alkaloid, has extensive pharmacological activity, including targeting breast cancer initiation cells and augmented the hypnotic effect of pentobarbital .Tetrandrine have the effect of analgesic and antipyretic,anti-inflammatory and inhibited infection of human white blood cells ,can be used as Blocking Ebola Virus.

Tetrandrine can inhibit the growth of breast cancer cells. It is founded that tetrandrine can inhibit primary mammosphere formation, a surrogate of breast cancer TICs in vitro in IC50 10 times lower than the IC50 of cell proliferation inhibition. Tetrandrine inhibits the mammosphere formation of cells isolated from fresh patient sample with similar IC50. Moreover, tetrandrine can decrease ALDH positive population, which is a putative marker for breast cancer TICs. In summary, tetrandrine can effectively targets in vitro breast cancer TIC surrogates. 

Tetrandrine potentiated pentobarbital (45 mg/kg, i.p.)-induced hypnosis significantly by reducing sleep latency and increasing sleeping time in a dose-dependent manner, and this effect was potentiated by 5-hydroxytryptophan (5-HTP). In the subhypnotic dosage of pentobarbital (28 mg/kg, i.p.)-treated mice, tetrandrine (60 and 30 mg/kg, p.o.) significantly increased the rate of sleep onset and also showed synergic effect with 5-HTP. Pretreatment of p-chlorophenylalanine (PCPA, 300 mg/kg, s.c.), an inhibitor of tryptophan hydroxylase, significantly decreased pentobarbital-induced sleeping time and tetrandrine abolished this effect.

Tetrandrine is a calcium channel blocker, calcium signaling is crucial to the ebolavirus infection process. The research showed that two-pore calcium channel 2 is the key signaling pathway. Tetrandrine may be more effective as a prophylactic treatment, tetrandrine shows an ability to stop the virus before it has a chance interact with cellular factors, thus stopping the virus from continuing its infection process.

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