Product Name: Total Matrines Appearance: brown powder to white crystalline powder It can improve the leucocyte deficiency symptoms so as to enhance the body’s immune function. c
Product Name: Total Matrines
Appearance: brown powder to white crystalline powder
Test Method: UV
Physical Property: Melting Point207
1.It can improve the leucocyte deficiency symptoms so as to enhance the body’s immune function.
2. With fungi and antibiotic resistent function, it is effective in dealing with trichomonad vaginitis, flagellate disease, amoeba dysentery and fungus dysentery, etc.
3. It can cure tonsillitis mastitis smooth the asthma etc. when taken orally.
4. It is also be widely used in pesticide because of it’s cheap price.
2.aluminum foil bag.
3.25kg paper drum with double plastic food grade bags inside.
4. pharmaceutical aluminum tin.
5. according to customer request.
Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines. The root is known as Ku shen. is a typical traditional Chinese medicine.
S. flavescens is an evergreen slow growing shrub growing to 1.5 m (4.9 ft) by 1 m (3.3 ft). It is hardy to 0–10 °F (-18 – -12 °C) and to US zone 6. The plant prefers light (sandy), medium (loamy) and heavy (clay) soils and requires well-drained soil. The plant prefers acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It requires moist soil. Like many other species in the Fabaceae family, this species can fix nitrogen.
Matrine, a alkaloid of the root of Sophora flavescens, has multiple protective effects on the cardiovascular system including cardiac arrhythmias. However, the molecular and ionic mechanisms of matrine have not been well investigated. Our study aimed at to shed a light on the issue to investigate the antiarrhythmic effects of matrine by using ouabain to construct an arrhythmic model of cardiomyocytes. In this experiment, matrine significantly and dose-dependently increased the doses of ouabain required to induce cardiac arrhythmias and decreased the duration of arrhythmias in guinea pigs. In cardiomyocytes of guinea pigs, ouabain 10 [micro]M prolonged action potential duration by 80% (p < 0.05) and increased L-type [Ca.sup.2+] currents and [Ca.sup.2+] transients induced by KC1 (p<0.05). Matrine 100 [micro]M shortened the prolongation of APD and prevented the increase of L-type [Ca.sup.2+] currents and [Ca.sup.2+] transients induced by ouabain. Taken together, these findings provide the first evidence that matrine possessed arrhythmogenic effect of ouabain by inhibiting of L-type [Ca.sup.2+] currents and [Ca.sup.2+] overload in guinea pigs.
Matrine is an alkaloid (Fig. 1) isolated from Sophora flavescens Ait (SF) and has been identified as the bioactive component contributing to a variety of pharmacological effects such as hepatitis B and C, cancers, and cardiac diseases. In clinics, matrine is currently used to treat cardiac arrhythmias, especially premature ventricular beats reported that the effects of an ethanol extract of the plant Sophora flavescens Ait possessed antiarrhythmic activity. Based on our previous research, we found that matrine possessed antiarrhythmic effect in experimental arrhythmic models induced by coronary artery ligation and electric stimulation in rats and rabbits. Matrine exerts its anti-AF effects by down-regulation of /Km3 density and up-regulation of. In addition, matrine enhanced [[Ca.sup.2+].sub.i] by stimulating [I.sub.Ca-L] and exerted positive inotropic effects in guinea pigs papillary muscles?
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